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The phosphorylated HER3 offers docking web sites for p85 subunit of PI3K. The completely activated PI3K advanced is created by binding of p110 subunit of PI3K to p85 which is ready to deliver PIP3 by using phosphorylating the PIP2. AKT binds to PIP3 and is particularly phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at equally threonine a